InSysBio to take part in ACoP 2024

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Conference
September 11, 2024

InSysBio announces its participation in the 15th American Conference on Pharmacometrics (ACoP) which is to be held from November 10-13, 2024, at the Arizona Grand Resort & Spa in Phoenix, Arizona, USA. Oleg Demin Jr, Scientific Director, Oncology & Immuno-Oncology, will be a co-chair and speaker of the session "Advancing QSP: From Virtual Patient To Digital Twin" on Tuesday, November 12, 2:00 PM – 3:30 PM MST, Location: Kaibab & Lantana. Oleg will give a talk "QSP modeling of engineered autologous T-cell therapies: random virtual patients vs virtual twins” at 2:20 PM – 2:40 PM MST in frames of the session.

InSysBio team is going to present its modeling services & software to optimize drug development at the Booth #11 and 9 posters in frames of the Conference, namely:
 
Monday, November 11, 7:00 AM – 5:00 PM MST:

  • M-024 "Mechanistic translational modeling versus minimal anticipated biological effect level approach to predict first-in-human dose for T-cell engagers: HPN536 case study" by Oleg Demin Jr, Galina Kolesova, Dmitry Shchelokov

Tuesday, November 12,  7:00 AM – 5:00 PM MST:

  • T-047 "FIVEDB as a tool for analysis of in vitro experimental data: cytokine production by primary cells and cell lines" by Ekaterina Goryacheva, Anna Kopeikina, Almina Polinova, Nail Gizzatkulov, Alexander Stepanov, Oleg Demin

Wednesday, November 13, 7:00 AM – 1:45 PM MST:

  • W-004 "Development of QSP model of non-small cell lung cancer and its application to select optimal dose for acasunlimab, a bispecific antibody targeting 4-1BB and PD-L1" by Gaurav Bajaj1, Alexandra Diakonova2, Sergey Smirnov2, Anna Roskoshnaia2, Ivan Borisov2, Patricia Garrido Castro3, Nora Pencheva3, Maria Jure-Kunkel1, Beesan Tan4, Tim Maiwald4, Manish Gupta1, Oleg Demin5, Craig Thalhauser1

Affiliation: (1) Genmab, Plainsboro, NJ, USA; (2) InSysBio CY, Paphos, Cyprus; (3) Genmab Utrecht, Netherlands; (4) BioNTech SE, Mainz, Germany; (5) InSysBio UK, Edinburgh, UK

  • W-005 "Utilizing PBPK/RO model for description of GEN1042 (BNT312) PK and prediction of trimer level to guide dose selection" by Gaurav Bajaj1, Dmitry Shchelokov2, Oleg Demin Jr2, Homer Adams III1, Summer Feng1, Leonid Gibiansky3, Saskia van der Lee4, Anandhi Johri1, Alexander Muik5, Porntula Panorchan5, Manish Gupta1, Oleg Demin6, Craig Thalhauser1 

Affiliation: (1) Genmab, Plainsboro, NJ, USA; (2) InSysBio CY, Limassol, Cyprus; (3) QuantPharm LLC, North Potomac, MD, USA; (4) Genmab, Utrecht, The Netherlands; (5) BioNTech SE, Mainz, Germany; (6) InSysBio UK, Edinburgh, UK

  • W-006 "Application of identifiability analysis to obtain reliable parameters of the QSP model describing mechanism of action GEN1042 (BNT312) and acasunlimab" by Evgeny Metelkin1, Ivan Borisov1, Sergey Smirnov1, Oleg Demin2, Gaurav Bajaj3, Jordan Blum3, Maria Jure-Kunkel3, Beesan Tan4, Tim Maiwald4, Manish Gupta3, Craig Thalhauser3

Affiliation: (1) InSysBio CY, Paphos, Cyprus; (2) InSysBio UK, Edinburgh, UK; (3) Genmab US, Inc, Plainsboro, NJ, (4) BioNTech SE, Mainz, Germany

  • W-060 "Quantitative systems pharmacology model for distinguishing efficacy of anti-CD20 therapy variants in populations of Multiple Sclerosis patients" by Tatiana Karelina, Oleg Demin, Dmitry Gordeev, Mariia Myshkina
  • W-061 "Quantitative systems pharmacology modeling of neurotoxicity and cognitive scores in Alzheimer’s disease for prediction of therapy outcomes" by Tatiana Karelina1, Valeriu Damian2, Oleg Demin3, Stepan Lerner1, Polina Maliukova1, Mahadevabharath Somayaji2, Olga Ivanova1

Affiliation: (1) InSysBio CY, Paphos, Cyprus; (2) GSK, Collegeville, PA, US; (3) InSysBio UK, Edinburgh, UK

  • W-072 "Unraveling Major Inflammatory Cytokines Serum Distribution Patterns in Systemic Lupus Erythematosus Patients: Insights from the CYTOCON Database" by Vladislav Leonov, Ekaterina Mogilevskaya, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
  • W-107 “Mechanistic Modeling Of Surface Molecule Interactions: Impact Of Methodology On CAR-T Cell Dose Predictions" by Ruslan Salimgareev1, Oleg Demin Jr2, Oleg Demin3

Affiliation: (1) Lomonosov Moscow State University, Moscow, Russia; (2) InSysBio CY, Paphos, Cyprus; (3) InSysBio UK, Edinburgh, UK

Check out our posters and Booth #11 at ACoP 2024!

About InSysBio

InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com

October 2024
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1. 04 Oct 2024 16:13 InSysBio to participate in SITC 2024 InSysBio announces its participation in SITC’s 39th Annual Meeting which is to be held from November 6-10, 2024, at George R. Brown Convention Center in Houston, TX, USA. InSysBio team is going to present its Mechanistic modeling services and tools to support development of immunotherapies at Booth #1032 and 3 posters in frames of the Meeting
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1. 16 Oct 2024 19:36 InSysBio to take part in "An Introduction to QSP" event InSysBio announces its participation in An Introduction to QSP, A UK QSP Network hybrid (in person/online) event which is to be held 17-20hrs 24th October 2024. Oleg Demin Jr, Scientific Director, Oncology & Immuno-Oncology, will discuss the prediction of the first-in-human dose for T-cell engagers using mechanistic modelling
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