InSysBio announces its participation in JuliaCon Global 2026 (Conference on the Julia programming language) which is to be held from August 10-15, 2026 at Johannes Gutenberg University Mainz, Germany. Ivan Borisov, Senior Software Developer, InSysBio, and Evgeny Metelkin, Technology Director, InSysBio, will give a talk:
August 12, 12:00–12:15 (Europe/Berlin), Room 4:
Ivan comments on the talk, "Virtual Populations (VPops) are widely used in Quantitative Systems Pharmacology (QSP) to represent variability in patient responses to therapy using parameterized dynamical models. Unlike traditional modeling approaches that focus on average treatment effects, VPop methods aim to reproduce the full distribution of clinical outcomes observed in trials.
We introduce VPopMIP, a Julia package implementing a Mixed-Integer Programming (MIP) formulation for generating VPops that match clinical endpoints. In contrast to many existing approaches that require individual-level patient data, VPopMIP enables calibration to published clinical summary statistics (e.g., response rates, medians, and confidence intervals), which are more commonly available in practice.
The method formulates virtual patient selection as a constrained optimization problem that enforces agreement with multiple outcome measures across therapies.
We demonstrate the methodology using a solid tumor model with multiple efficacy endpoints across treatment regimens. The results illustrate how MIP-based selection provides an efficient way to construct clinically consistent virtual populations".
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio's cutting-edge QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry and innovative biotech companies. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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09 Mar 2017 14:10
ISBM Enclosed Conference was held
20-22 February 2017 the 10th ISBM Enclosed Conference was held. For ten years the employees annually have been meeting together to share their scientific results and talk over future plans. ISBM did a great job in this working year.
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15 Mar 2017 11:49
Institute for Systems Biology participates in American Society for Clinical Pharmacology and Therapeutics 2017 Meeting
Institute for Systems Biology Moscow – a company, providing modeling services for innovative drug design, announced participation in ASCPT 2017 Meeting, which is held on 15-18 March in Washington, DC. ISBM will present several studies and demonstrate an updated version of platform for quantitative systems pharmacology modeling of immune response - Immune Response Template (IRT).
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28 Mar 2017 17:56
Not all therapies are effective: Institute for Systems Biology Moscow to present the results of the Alzheimer’s disease Systems Pharmacology Modeling
Moscow, Russia – March 28, 2017. On the 1st April, Tatyana Karelina, ISBM leading specialist in neurodegenerative field, will present a poster entitled "Amyloid toxicity and different mechanisms of action for amyloid-targeted treatments studied by quantitative systems pharmacology model" at the 13th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders to be held on March 29 - April 2, Vienna, Austria.
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