September 26, 2018
InSysBio, a pioneer in Quantitative Systems Pharmacology (QSP) modeling and simulation for drug development, today announced the launch of Immune Response Template (IRT) online. IRT is a QSP platform of human immune system and a tool for development of custom QSP models related to immune response.
Immune Response Template is an innovative tool allowing users to select all or any reactions and species from IRT Core Model, QSP model of immune response in humans, and download it.
Previous version of IRT has been successfully used for development of models in various therapeutic areas: autoimmune diseases (SLE), respiratory diseases (asthma and COPD), and immuno-oncology (melanoma, NSCLC, AML, ALL, multiple myeloma). Eight pharmaceutical companies became users or previous version of the platform. IRT was significantly updated during last year including significant improvement of MDSC description, description of immunological synapses with various co-stimulatory and co-inhibitory receptors, etc.
“IRT creates a unique opportunity for QSP modelers: instead of spending time on early stages of model development such as collection of experimental data, derivation of equations, identification of parameters against in vitro data, one can just use IRT and select required reactions and species, download the model with selected elements and use it as a basis of model of particular disease. Thus, IRT allows users to reduce the model development time by weeks or even months,” said Oleg Demin Jr, IRT project leader.
About InSysBio
InSysBio is a Quantitative Systems Pharmacology (QSP) company located in Moscow, Russia (INSYSBIO LLC) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative approach has already become a part of the drug development process implemented by our strategic partners: nowadays there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. The company has published multiple scientific studies in various therapeutic areas. InSysBio team is developing software and tools for QSP and continuously improves methods for biological modeling. For more information about InSysBio, its solutions and services, visit http://insysbio.com.
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14 Jul 2017 18:49
To predict unpredictable: a platform for modeling of the high-selective oncology drugs was created
Moscow, Russia, July 14, 2017. The scientists from BIND RUS and InSysBio (www.insysbio.ru) published a joint research of the new class of anti-oncology treatment in the Journal of Controlled Release. Unique nanoparticles enriched with medications can deliver its content targeted to the tumor site, and the parameters of their effectiveness are programmed during the forming phase.
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25 Jul 2017 13:50
InSysBio LLC Announce Renewal of Agreement with ASTEX Pharmaceuticals Inc.
Moscow, Russia, July 25, 2017 – InSysBio LLC (www.insysbio.ru), one of the pioneers in Quantitative Systems Pharmacology (QSP) modeling and simulation for drug development, announced today a renewal of multi-year Master Service Agreement with ASTEX Pharmaceuticals, Inc.
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25 Jul 2017 17:37
InSysBio will present at the American Conference on Pharmacometrics (ACoP8)!
Moscow, Russia, July 26, 2017. - Event announcement. This year the scientific team of InSysBio will make 9 poster presentations in conjunction with leading pharmaceutical companies at ACoP8. Also at the special session "QSP Modular design - Approaches to speed up the QSP model development" Oleg Demin Jr will hold a workshop on modeling with the Immune Response Template (IRT) platform.
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