February 21, 2020
IRT Version 3.0.0 acquires a wide variety of updates and new options
(Moscow – 21.02.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) platform development and provision, moves forward to the future. According to InSysBio Top Officials, the report on the latest amendments within the IRT was yesterday presented at the company’s internal seminar. Veronika Musatova, Head of IRT development team, highlights, “The new version is mainly aimed to boost and facilitate the development of QSP models in immunology and immuno-oncology therapeutic areas. Previously IRT was mainly addressed to as a kind of manual on immune cell interactions and regulations rather than fully-fledged database and now it is rethought to be an efficient and useful tool”.
Actually, new schemes and players were added into the database, total revision of core model reactions and parameters was introduced. Moreover, a great variety of new cell types and regulatory molecules has become represented. One of the advantages of the IRT is implementation of a method allowing to translate in vitro measured EC50/IC50 of regulatory cytokine effects into in vivo model. Due to QSP modeling technologies drug development acquires dramatic efficiency increase. Globally the QSP modeling assists to determine the optimal doses, target groups of patients and substances effect on the human body. These advantages of QSP modeling are enabled by the fact that mathematical models represent virtual constructions based on experimental data and real objects’ features. Application of IRT allows to simplify routine work on QSP model development and calibration by using calibrated sub-models exported from IRT as building blocks.
In comparison with the previous versions of IRT the latest one provides higher quantity of identified parameters, namely about 60% of them have been identified. Particularly, schemes and equations according to introduced cell types have been revised. New regulatory molecules are added in descriptions of cells proliferation, apoptosis, migration and activation.
Veronika Musatova outlines, “Our further soft development is underway, for instance cytokines sources profiles and new models are expected to appear. Some outdated information is being actualized”.
About InSysBio:
InSysBio is a Quantitative Systems Pharmacology (QSP) company located in Moscow, Russia (INSYSBIO LLC) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com.
For more information about IRT Version 3.0.0, please visit irt.insysbio.com.
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01 Oct 2018 12:23
InSysBio Announces Continuation of Collaboration with MedImmune for Quantitative Systems Pharmacology Modeling in Systemic Lupus Erythematosus
InSysBio, a pioneer in Quantitative Systems Pharmacology (QSP), modeling and simulation for drug development, announced today an extension of a collaboration with MedImmune, the global biologics research and development arm of AstraZeneca, for QSP modeling in systemic lupus erythematosus (SLE). The goal is to support the clinical development of anifrolumab, an investigational monoclonal antibody against the type I interferon receptor, by modeling the contributions of key cell types involved in the pathophysiology of lupus that are associated with the type I interferon dysregulation commonly seen with the disease.
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02 Oct 2018 14:05
InSysBio to present at ACoP9
InSysBio announces their participation at Ninth American Conference on Pharmacometrics (ACoP9), to be held October 7th to 10th, 2018, at the Loews Coronado Bay Resort near San Diego, CA. The theme of ACoP9 is “Modeling without Bounds”. InSysBio welcomes visitors at the booth #23.
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09 Oct 2018 15:29
InSysBio starts training course “Modeling for systems biology and biomedicine”
InSysBio expert modelers Dr. Galina Lebedeva, Dr. Tatiana Karelina, Dr. Evgeny Metelkin and Dr. Oleg Demin will give the course “Modeling for systems biology and biomedicine” at the Faculty of bioengineering and bioinformatics, Lomonosov Moscow State University.
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19 Oct 2018 15:49
InSysBio to present at BiotechClub 2018
InSysBio announces their participation at BiotechClub 2018 conference to be held on October 26th at Hyatt Regency Moscow Petrovsky Park. The theme of BiotechClub 2018 is “From Systems Biology to Systems Medicine”.
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24 Oct 2018 13:49
InSysBio to present at ICSB 2018
InSysBio announces their participation at 19th International Conference on Systems Biology (ICSB 2018) to be held October 28th to November 1st, 2018 in Lyon, France.
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