January 16, 2023
The new article “Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study” by Dmitry Shchelokov and Oleg Demin Jr was published in mAbs journal at the end of December 2022.
Oleg Demin Jr comments on the article, “Mechanistic description of biomarkers and endpoints is necessary for accurate analysis of the clinical trial results and prediction of these outcomes by QSP modeling. One of these endpoints is target receptor occupancy which is measured in early clinical trials for therapeutic antibodies including monoclonal and bispecific ones, etc. In the published article we have shown that the method of target occupancy measurement can affect the results of clinical trials and their interpretation”.
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Edinburgh, UK (INSYSBIO UK LIMITED), Limassol, Cyprus (INSYSBIO CY Ltd) and Moscow, Russia (INSYSBIO LLC). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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07 Jul 2021 12:40
InSysBio to present its posters at AAIC 2021
InSysBio announces its participation in AAIC 2021 (Online). Alzheimer's Association International Conference is held in Denver, USA and Online in July 26-30, 2021. InSysBio Neurodegeneration Diseases team presents two posters within its frames
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22 Jul 2021 16:03
InSysBio to present Immune Response Template v. 3.5.0
Now IRT gets significant update and a portion of new data
[Moscow – 22.07.2021] InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, launches Immune Response Template (IRT) version 3.5.0.
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28 Jul 2021 16:26
InSysBio to take part in ESMO Congress 2021
InSysBio announces its participation in ESMO (European Sosiety For Medical Oncology) Virtual Congress 2021 which is held on September 16-21. InSysBio team's abstract was accepted
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