InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, announces the extension of collaboration with discoveric bio alpha, a biotechnology company taking next generation antibody technologies into Alzheimer’s Disease.
Previously mechanistic model predicting concentration of monoclonal antibodies (mAbs) and target occupancy in cerebrospinal fluid was developed by InSysBio in collaboration with discoveric bio alpha. The further project expansion aims to use the model to support first-in-human study of NIDB-3101 leveraging cyno-to-human translation and available published clinical data as benchmarks.
Jean-Philippe Courade, CSO of discoveric bio alpha, comments on the project extension, “We were inspired to experience InSysBio’s cutting-edge mechanistic modeling approach during our first collaboration. Now we are excited to continue the project that will provide us with a range of new predictions to efficiently advance through the next stages of our antibody development”.
Oleg Demin Jr, Scientific Director, InSysBio, highlights, “We are encouraged by the opportunity to implement our expertise and solutions to further unleash the potential of the model. With its help we will support the selection of the starting dose and pharmacologically active dose to optimize first-in-human study”.
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s cutting-edge QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry and innovative biotech companies. For more information about InSysBio, its solutions and services, visit www.insysbio.com
About discoveric bio alpha
discoveric bio alpha is a privately owned company part of a group of three separate companies dedicated to the development of novel therapeutics for the treatment of Alzheimer’s Disease, Neuroinflammation and Antimicrobial Resistant infections. It is located in Pfäffikon, Switzerland. For more information, visit https://www.discovericbio.com/
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04 Oct 2024 16:13
InSysBio to participate in SITC 2024
InSysBio announces its participation in SITC’s 39th Annual Meeting which is to be held from November 6-10, 2024, at George R. Brown Convention Center in Houston, TX, USA. InSysBio team is going to present its Mechanistic modeling services and tools to support development of immunotherapies at Booth #1032 and 3 posters in frames of the Meeting
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16 Oct 2024 19:36
InSysBio to take part in "An Introduction to QSP" event
InSysBio announces its participation in An Introduction to QSP, A UK QSP Network hybrid (in person/online) event which is to be held 17-20hrs 24th October 2024. Oleg Demin Jr, Scientific Director, Oncology & Immuno-Oncology, will discuss the prediction of the first-in-human dose for T-cell engagers using mechanistic modelling
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