Now B cells model reflects the current views on the processes

NEWS
Press-Release
Software
September 4, 2024

InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, launches Immune Response Template (IRT) version 3.6.3. IRT represents a QSP platform of immune system, simultaneously, being a tool for development of models related to immune system.

Initially, IRT is based on two main components. On the one hand, it is a fully-fledged database including a wide variety of features covering the immune system. On the other hand, it comprises Navigator that provides intuitive interface to interact with IRT Database. Thus, a modeler can apply calibrated sub-models exported from IRT as building blocks to simplify the model development process.

IRT is a part of InSysBio’s QSP software infrastructure being under constant upgrade. IRT v.3.6.3 gets a range of new features:

  • Model of B cell lifecycle was updated.
  • New cell types were added:  Germinal center B cells (GC_B), effector B cells (efB), Germinal center plasma cells (gcPC), B memory cells activated (Bmem_a), long-lived plasma cells (LLPC).
  • The velocity equations were expanded, modifiers were added: T helper cells (Th), CCL13, CCL20, Dendric cells activated (cDCa, MoDCa).

Veronika Musatova, Head of IRT development team, comments on the new version, “As a result of the update, B cells model reflects the current views on the processes and sequence of this cell type development maintaining a balance between the model detail and complexity.”

To learn the full content of Immune Response Template, please visit irt.insysbio.com.

To get demo access to IRT, please click “sign in” or “user account” on the irt.insysbio.com.

To get more information on any tool or leave your feedback, please feel free to contact us: support@insysbio.com

About InSysBio

InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com

July 2017
MoTuWeThFrSaSu
     
1
2
3
4
5
6
7
8
9
10
11
12
13
14
1. 14 Jul 2017 18:49 To predict unpredictable: a platform for modeling of the high-selective oncology drugs was created Moscow, Russia, July 14, 2017. The scientists from BIND RUS and InSysBio (www.insysbio.ru) published a joint research of the new class of anti-oncology treatment in the Journal of Controlled Release. Unique nanoparticles enriched with medications can deliver its content targeted to the tumor site, and the parameters of their effectiveness are programmed during the forming phase.
15
16
17
18
19
20
21
22
23
24
25
1. 25 Jul 2017 13:50 InSysBio LLC Announce Renewal of Agreement with ASTEX Pharmaceuticals Inc. Moscow, Russia, July 25, 2017 – InSysBio LLC (www.insysbio.ru), one of the pioneers in Quantitative Systems Pharmacology (QSP) modeling and simulation for drug development, announced today a renewal of multi-year Master Service Agreement with ASTEX Pharmaceuticals, Inc.
2. 25 Jul 2017 17:37 InSysBio will present at the American Conference on Pharmacometrics (ACoP8)! Moscow, Russia, July 26, 2017. - Event announcement. This year the scientific team of InSysBio will make 9 poster presentations in conjunction with leading pharmaceutical companies at ACoP8. Also at the special session "QSP Modular design - Approaches to speed up the QSP model development" Oleg Demin Jr will hold a workshop on modeling with the Immune Response Template (IRT) platform.
26
27
28
29
30
31
      
Upcoming Events
Tags
Latest News
29.10
InSysBio to announce its collaboration with BeOne Medicines
16.10
InSysBio to introduce a new data annotation service available in CYTOCON DB and fIVE DB
19.08
InSysBio to publish the new article "Revolutionizing drug discovery: Integrating artificial intelligence with quantitative systems pharmacology"
05.08
InSysBio to launch Immune Response Template Open for QSP modeling
25.06
InSysBio to announce extension of collaboration with discoveric bio alpha